tag:blogger.com,1999:blog-32683882.post116053139716482485..comments2023-07-29T02:58:08.990-05:00Comments on BioMed Notes: Autoimmunity and Ubiquitin ligasesUnknownnoreply@blogger.comBlogger2125tag:blogger.com,1999:blog-32683882.post-1160531954209846572006-10-10T20:59:00.000-05:002006-10-10T20:59:00.000-05:00This recent JEM paper by Derbinski et al. [nih.gov...This recent JEM paper by <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=15983066&dopt=Abstract" REL="nofollow" TITLE="nih.gov">Derbinski et al.</A> [nih.gov] shows that some regions of the genome are transcriptionally active in thymic epithelial cells. These regions include AIRE-dependent and -independent genes (promoters).Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-32683882.post-1160531875513388562006-10-10T20:57:00.000-05:002006-10-10T20:57:00.000-05:00The Anderson paper demonstrates a strong regulatio...The Anderson paper demonstrates a strong regulation by AIRE of ectopic gene expression in the thymus, most clearly insulin by quantitative PCR. However, AIRE deficient mice are apparently <B>not diabetic</B> (corrections welcome) and less than 20% of humans with AIRE mutations are diabetic (the cited review). Thus, the link between ectopic expression in the thymus and disease is not very strong.Anonymousnoreply@blogger.com