tag:blogger.com,1999:blog-32683882.post1821497790069131959..comments2023-07-29T02:58:08.990-05:00Comments on BioMed Notes: Interleukin-1 in Systemic Juvenile arthritisUnknownnoreply@blogger.comBlogger1125tag:blogger.com,1999:blog-32683882.post-69701153821430930802007-01-21T20:45:00.000-05:002007-01-21T20:45:00.000-05:00IL-6 implicated in SoJIA
This paper [nih.gov] ...<b>IL-6 implicated in SoJIA </b> <br /><br />This <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15987476&query_hl=1"> paper</A> [nih.gov] by Miyamae et al. reports examining the sera of 8 SoJIA patients who responded to "conventional therapy" (steroids and NSAIDs (non-steroidal anti-inflammatory drugs)) and 15 who did not respond. The non-responders did respond to an experimental therapy with an antibody the the IL-6 receptor (MRA). They found reproducible differences in the sera of patients before vs. after treatment. Most of the differences were observed with both treatments, suggesting they may be good markers of the disease process (instead of a treatment effect). One of these markers was serum amyloid A, which was already known to be associated with SoJIA.Reuelhttps://www.blogger.com/profile/00375847200584931533noreply@blogger.com