tag:blogger.com,1999:blog-32683882.post8715887397559033389..comments2023-07-29T02:58:08.990-05:00Comments on BioMed Notes: Overreacting to Infection is Dangerous to Your HealthUnknownnoreply@blogger.comBlogger1125tag:blogger.com,1999:blog-32683882.post-28851955336495795462009-09-22T08:15:41.047-05:002009-09-22T08:15:41.047-05:00Several differentially-spliced isoforms of CD45 ar...Several differentially-spliced isoforms of CD45 are expressed by T cells at different steps in their maturation from naive to memory (see <a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151460" rel="nofollow">OMIM entry here</a>). I'm curious whether the "wild-type" ratios are disturbed in these CD45-62% mice. Also, since CD45 is a phosphatase that acts to terminate signaling, couldn't less of it allow for a *stronger* (or protracted) immune response?Reuelhttps://www.blogger.com/profile/00375847200584931533noreply@blogger.com