Tuesday, November 7, 2006

J Exp Med Classics online

drj writes "The Journal of Experimental Medicine has produced pdf (Acrobat) versions of all papers they've published since 1896! Now you can peruse the classic 1944 Avery, MacLeod, and McCarty paper that first showed “desoxyribonucleic acid” (DNA) was the “transforming substance”. Or, one of their follow-up papers, for example an "Improved Method for the Isolation of the Transforming Substance”, very early in a very long string of DNA methods papers. Or here’s one of my favorites, the genetic regulation of the immune response. For a glance backward at less memorable papers, try the I-J era. Three cheers and much appreciation to the publisher, the
Rockefeller University Press, with support from The Medical Library Center of New York. This stuff is too old for PubMed (which covers back to the mid-1960s) and even for OLDMEDLINE, which currently goes back to 1951. You’ve got to seek and find it on your own. Search here for your favorite classics (old and new).
What's your favorite J Exp Med paper?"

2 comments:

Reuel said...

I-J Redux

Could non-classical genes reside within the I-J region? Even small transcripts or regulatory sequences might explain some phenomena attributed to this region. I-J-encoded epitopes on secreted products are hard to explain but they could conceivably be encoded on molecules whose expression is controlled by sequences within I-J.

cDNA library said...

"Improved Method for the Isolation of the Transforming Substance”, very early in a very long string of DNA methods papers is recommended.